SPRAY-DRIED CO-AMORPHOUS TADALAFIL TERNARY MIXTURES: A PROMISING PLATFORM TOWARDS THE ENHANCEMENT OF SOLUBILITY AND BIOAVAILABILITY

Spray-dried co-amorphous Tadalafil ternary mixtures: a promising platform towards the enhancement of solubility and bioavailability

Abstract Tadalafil (Tad) is a poorly water-soluble drug (BCS class II) that is used for the treatment of erectile dysfunction.An enhancement of aqueous solubility Spot Gel is vital to accelerate its onset of action and subsequently enhance its therapeutic effect.Binary and ternary mixtures of Tad with different amino acids (histidine, valine, alani

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The hidden financial burden of healthcare: a systematic literature review of informal payments in Sub-Saharan Africa [version 1; peer review: 1 approved, 2 approved with reservations]

Background: Informal payments limit equitable access to healthcare.Despite being a common phenomenon, there is a need for an in-depth analysis of informal charging practices in the Sub-Saharan Africa (SSA) context.We conducted a systematic literature review to synthesize existing evidence on the prevalence, characteristics, associated factors, and

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